False-Negative Results in Lung Cancer Screening—Evidence and Controversies

Identifying false-negative cases is an important quality metric in lung cancer screening, but it has been infrequently and variably reported previous studies. Although as a proportion of all screening participants, are uncommon, such may constitute substantial cancers diagnosed (up to 15%) within program.This article reviews the impact causes tests, including those related radiologic evaluation, nodule management protocols, decisions made by multidisciplinary teams. Following review data from international studies, this discusses controversies literature surrounding definition classification test how on rates should be captured recorded. Challenges, avoiding overly cautious surveillance nodules while minimizing overdiagnosis investigation indolent or benign lesions, considered. Finally, advantages disadvantages different approaches dealing with results discussed.